Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection.
Innate immunity is the first line of defense against invading microorganisms.Trypanosome Lytic Factor (TLF) is a minor sub-fraction of human high-density lipoprotein that provides innate immunity by completely protecting humans from infection by most species of African trypanosomes, which belong to the Kinetoplastida order.Herein, we demonstrate th